Key result
Titin plays a crucial role in muscle elasticity, with its elongation and compression within the sarcomere likely occurring in a more ordered way or with higher viscosity than observed in solution.
Population
Isolated titin molecules from vertebrate striated muscle and in situ sarcomere models
Design
Review
Authors
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Refines sarcomere elasticity model; leaves open titin modulation for cardiac diastolic function.
The structural transitions of the giant protein titin, including domain unfolding, govern the passive elasticity of striated muscle, with implications for understanding muscle mechanics in confined sarcomeric spaces.
Tskhovrebova et al. (2002) reported a review. Titin was evaluated. Titin plays a crucial role in muscle elasticity, with its elongation and compression within the sarcomere likely occurring in a more ordered way or with higher viscosity than observed in solution.
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