Key result
Chronic progressive external ophthalmoplegia leads to severe conduction disease and myocardial hypertrophy requiring permanent pacing.
Case Report (n=1)
This report describes heart disease in a 32-year-old man with the syndrome of chronic progressive external ophthalmoplegia (CPEO). The surface electrocardiogram showed first degree AV block and left bundle-branch block and there was HV prolongation on the His bundle electrogram. Endomyocardial biopsy showed the changes of hypertrophy on light microscopy, and on electron microscopy there were increased numbers of mitochondria which appeared structurally normal. A permanent demand pacemaker was inserted because these patients are prone to develop complete heart block.
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McComish et al. (1976) conducted a case report in Chronic progressive external ophthalmoplegia (CPEO) (n=1). Chronic progressive external ophthalmoplegia was evaluated on Cardiac conduction abnormalities and histological changes. A 32-year-old man with chronic progressive external ophthalmoplegia developed first degree AV block, left bundle-branch block, and myocardial hypertrophy, necessitating a permanent demand pacemaker.