Why the study?
While studies had examined cardiac remodeling in NAFLD, there had been less emphasis on the development of carotid atherosclerosis and stroke.
Does non-alcoholic fatty liver disease increase the risk of carotid atherosclerosis and ischemic stroke?
Population
135,602 individuals across multiple studies
Comparison
Patients with NAFLD vs non-NAFLD
Design
Meta-analysis
Key result
Non-alcoholic fatty liver disease was associated with a significantly increased risk of carotid atherosclerosis (OR 3.20) and stroke (OR 1.88) compared to non-NAFLD controls.
Authors
Loading...
Supports vascular monitoring in NAFLD; hypothesis-generating for outcome-changing trials.
Meta-Analysis (n=135,602)
Does non-alcoholic fatty liver disease increase the risk of carotid atherosclerosis and ischemic stroke?
Odds Ratio: 3.2 (95% CI 2.37–4.32)
p-value: p=<0.0001
NAFLD is associated with a significantly increased risk of carotid atherosclerosis and ischemic stroke, suggesting the need for routine carotid assessment in these patients.
Tang et al. (2022) conducted a meta-analysis in Non-alcoholic fatty liver disease (NAFLD) (n=135,602). Non-alcoholic fatty liver disease (NAFLD) vs. Non-NAFLD controls was evaluated on Carotid atherosclerosis (OR 3.20, 95% CI 2.37-4.32, p=<0.0001). Non-alcoholic fatty liver disease was associated with a significantly increased risk of carotid atherosclerosis (OR 3.20) and stroke (OR 1.88) compared to non-NAFLD controls.