Key result
NAFLD linked to a ~0.12 mm increase in CIMT vs controls.
Why the study?
Although the relationship between cardiovascular disorders and NAFLD has been extensively studied, pooled data were needed to draw a more definite conclusion regarding its association with carotid intima-media thickness and cardiovascular disorders.
Is nonalcoholic fatty liver disease associated with increased carotid intima-media thickness and atherosclerotic plaques?
Meta-Analysis (n=42,299)
Is nonalcoholic fatty liver disease associated with increased carotid intima-media thickness and atherosclerotic plaques?
Mean Difference: 0.1231 (95% CI 0.0462–0.2)
p-value: p=0.002
NAFLD is significantly associated with increased carotid intima-media thickness and a higher prevalence of carotid atherosclerotic plaques, suggesting an increased risk of cardiovascular disorders.
May warrant enhanced CV risk assessment in NAFLD; confirms observational link to subclinical atherosclerosis but leaves causality open.
Introduction The relationship between cardiovascular disorders and nonalcoholic fatty liver disease (NAFLD) has been extensively studied. To better pool this data and make a more definite conclusion, we performed a meta‐analysis to evaluate the association between NAFLD and the thickness of media and intima of carotid artery (CIMT) and cardiovascular disorders. Methods We searched PubMed, Ovid, Scopus, ProQuest, Web of Science, and the Cochrane Library, and analyzed the pooled data using R studio and the “metafor” package. Results The final analysis included a total of 59 studies with 16,179 cases and 26,120 control individuals. NAFLD was shown to be associated with an increase of 0.1231 mm (20.6%) in carotid artery intima‐media thickness (CIMT) ( p = 0.002, 95% confidence interval [CI]: 0.0462–0.2000) in individuals with NAFLD. The prevalence of atherosclerotic plaques in the carotid arteries and the occurrence of NAFLD are significantly correlated, according to a meta‐analysis based on 17 distinct studies ( p = 0.001, 1.28–1.43, 95% CI, odds ratio = 1.356). Conclusion Patients with increased CIMT are considerably more likely to have NAFLD. Large prospective investigations are required to corroborate these findings and their prognostic significance, along with the effectiveness of the available interventions.
No takes yet. Share an insight, caveat, or question.
Khoshbaten et al. (2023) conducted a meta-analysis in Nonalcoholic fatty liver disease (n=42,299). Nonalcoholic fatty liver disease vs. Without NAFLD was evaluated on Carotid artery intima-media thickness (CIMT) (MD 0.1231, 95% CI 0.0462-0.2000, p=0.002). Nonalcoholic fatty liver disease was associated with a 0.1231 mm increase in carotid artery intima-media thickness (95% CI 0.0462-0.2000; p=0.002) compared to individuals without NAFLD.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: