Key result
NAFLD linked to ~40% greater CIMT versus healthy controls.
Why the study?
Is nonalcoholic fatty liver disease associated with increased carotid intima-media thickness compared to healthy controls?
Case-Control (n=335)
Is nonalcoholic fatty liver disease associated with increased carotid intima-media thickness compared to healthy controls?
Absolute Event Rate: 0.81% vs 0.58%
p-value: p=0.001
Nonalcoholic fatty liver disease is independently associated with increased carotid intima-media thickness, suggesting it is an independent risk factor for atherosclerosis and cardiovascular events.
NAFLD may prompt CIMT evaluation during metabolic assessment; leaves open whether it independently predicts cardiovascular events.
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD), a highly prevalent condition, is a feature of metabolic syndrome and is characterized by excessive accumulation of fat in the liver cells. The purpose of this study was to investigate the association between NAFLD and carotid intima-media thickness (CIMT) as an independent risk factor for atherosclerosis. METHODS: We examined 250 consecutive patients with ultrasonographically confirmed NAFLD and 85 age-matched and gender-matched controls with normal parenchymal liver echogenicity for determination of CIMT and presence of carotid atherosclerotic plaque. RESULTS: Compared with control subjects, patients with NAFLD showed an increased mean CIMT (0.81 ± 0.14 mm) compared with control subjects (0.58 ± 0.15 mm). This difference was statistically significant (P = 0.001). After performing multivariate analysis, the presence of NAFLD was associated with abnormal CIMT independent of other atherogenic risk factors or its association with metabolic syndrome. CONCLUSION: NAFLD can be an independent risk factor for developing atherosclerosis. Therefore, NAFLD with and without metabolic syndrome can be associated with increased CIMT and increased risk of cardiovascular events in patients with NAFLD incidentally diagnosed on abdominal ultrasonography.
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Mohammadi et al. (2011) conducted a case-control in Nonalcoholic fatty liver disease (NAFLD) (n=335). Nonalcoholic fatty liver disease (NAFLD) vs. Normal parenchymal liver echogenicity was evaluated on Carotid intima-media thickness (CIMT) (p=0.001). Nonalcoholic fatty liver disease was associated with a significantly increased mean carotid intima-media thickness compared to controls (0.81 mm vs 0.58 mm; P=0.001).
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