Key result
Carotid intimal media thickness was significantly higher in NAFLD patients with predisposing factors compared to those without, and was higher in cases with moderate versus mild steatosis.
Why the study?
Is the severity of NAFLD and presence of metabolic risk factors associated with increased carotid atherosclerosis (CIMT)?
Cross-Sectional (n=72)
Single-blind
Is the severity of NAFLD and presence of metabolic risk factors associated with increased carotid atherosclerosis (CIMT)?
Answers are grounded in this paper and cite their sources.
In patients with NAFLD, the presence of metabolic risk factors and greater severity of hepatic steatosis are associated with increased carotid intima-media thickness, indicating a higher atherosclerotic burden.
Non-alcoholic fatty liver disease (NAFLD) is currently the most common cause of abnormal liver biochemistry and cryptogenic cirrhosis. Those with NAFLD have a higher prevalence of atherosclerosis, as shown by increased carotid artery intimal media thickness (CIMT). The aim of this study is to assess the co-incidence and prevalence between NAFLD and carotid atherosclerosis. In this study seventy-two subjects were categorized into 2 groups. GI: 52 patients diagnosed as NAFLD with diabetes mellitus type 2 or obesity or hyperlipedemia. GII: 20 diseased controls diagnosed as NAFLD without other predisposing factor. CIMT and plaque prevalence were estimated by carotid ultrasonography as a single trainedoperator who was blind to clinical characteristics of participants. The results showed that CIMT by carotid duplex ultrasonography was significantly higher in group A than group B but CIMT did not reveal any significant difference asregards to the etiology of NAFLD. CIMT was significantly higher in cases with bright liver than those with homogenous liver (by abdominal US) in group I and II. CIMT was significantly higher in those with moderate steatosis than those with mild steatosis (in GI & GII).
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EL-SAYED et al. (2014) conducted a cross-sectional in Non-alcoholic fatty liver disease (NAFLD) (n=72). NAFLD with predisposing factors (diabetes, obesity, hyperlipidemia) vs. NAFLD without other predisposing factors was evaluated on Carotid artery intimal media thickness (CIMT) and plaque prevalence. Carotid intimal media thickness was significantly higher in NAFLD patients with predisposing factors compared to those without, and was higher in cases with moderate versus mild steatosis.
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