Key result
The combination of physical stress and lipopolysaccharide significantly increased the atherosclerotic plaque disruption rate compared to controls (60.9% vs 16.7%, P=0.002) in apoE(-/-) mice.
RCT (n=96)
Randomly divided
Absolute Event Rate: 60.9% vs 16.7%
p-value: p=0.002
Stress and LPS co-stimulation in apoE(-/-) mice effectively induces atherosclerotic plaque disruption, providing a useful model for studying plaque vulnerability.
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Stress plus LPS elevates plaque disruption rates in apoE−/− mice; leaves open relevance to human plaque rupture and acute events.
Ni et al. (2009) conducted an RCT in Atherosclerotic plaque disruption (n=96). Stress and lipopolysaccharide (LPS) vs. Control was evaluated on Plaque disruption rate (p=0.002). The combination of physical stress and lipopolysaccharide significantly increased the atherosclerotic plaque disruption rate compared to controls (60.9% vs 16.7%, P=0.002) in apoE(-/-) mice.
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