There has been considerable work with focal injections of cholinergic compounds in the brain. Early work by Hernandez-Peon et al. 11, Mazzuchelli-O’Flaherty et al. 16, Cordeau et al. 4, George et al. 8, and Baxter1 suggests that cholinergic stimulation of the brain can induce sleep, REM sleep or motor inhibition akin to that seen in human cataplexy. Since the narcolepsy-cataplexy syndrome in humans is wide-spread 5,7 and has recently attracted much attention6,19, these sleep and motor inhibitory effects are of particular interest. An experimentally producible animal model of narcolepsy-cataplexy would be of use in evaluating treatments for cataplexy. To this end, an animal model of narcolepsy-cataplexy should show one or more of the following behaviors:
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Mitler et al. (1974) studied this question.
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