Photobiomodulation is a Physical and Chemical Event and its Cellular Mechanisms of Action in Pain: Objective Systematic Review.

This literature review presents the action of photobiomodulation (PBM) in the production of transmembrane proteins by neuronal cells to control transient pain, preventing this initial pain from becoming chronic. The literature collected can prove that this protein production pathway may be viable for anti-pain effects in humans. The search was conducted in four databases: PubMed, Google Scholar, and Web of Science. The keywords “photobiomodulation proteins” and “photobiomodulation pain” supplied the selection of papers issued in the last 2 years and the most cited papers on Google Scholar written in English. 10 recent and relevant articles were selected, of the papers found. All articles showed that PBM has a positive effect on pain, with one of them showing its effect on modulating protein production in cells. Articles have showed that PBM has a favourable effect on controlling transient peripheral pain. PBM has advantageous effects on transient peripheral pain. However, more experiments are necessary to clearly conclude this line of research, which can also be effective in chronic pain when applied to the correct areas in the brain.