Key result
Severe preeclampsia was associated with significantly elevated third-trimester plasma ADMA concentrations compared to normotensive pregnancies (0.55 vs 0.36 micromol/l; p<0.05).
Why the study?
Are circulating concentrations of ADMA and arginine altered in women with severe preeclampsia compared to normotensive pregnant women?
Population
24 pregnant women, comprising 12 with severe preeclampsia and 12 normotensive pregnant controls, sampled…
Design
Case-control
Follow-up
Up to 3 months postpartum
Authors
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Elevated ADMA in severe preeclampsia is hypothesis-generating; leaves open its value as biomarker or therapeutic target.
Case-Control (n=24)
Are circulating concentrations of ADMA and arginine altered in women with severe preeclampsia compared to normotensive pregnant women?
Absolute Event Rate: 0.55% vs 0.36%
p-value: p=<0.05
Elevated circulating ADMA concentrations and a lower arginine/ADMA ratio in the third trimester suggest that endogenous nitric oxide synthesis inhibitors may play a pathophysiological role in severe preeclampsia.
Pettersson et al. (1998) conducted a case-control in Severe preeclampsia (n=24). Severe preeclampsia vs. Normotensive pregnancy was evaluated on Plasma ADMA concentration during the third trimester (micromol/l) (p=<0.05). Severe preeclampsia was associated with significantly elevated third-trimester plasma ADMA concentrations compared to normotensive pregnancies (0.55 vs 0.36 micromol/l; p<0.05).
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