Key result
Regenerated endothelial cells 6 weeks after balloon denudation in rabbits showed significantly higher L-NMMA and ADMA contents and decreased L-arginine compared to control cells.
Population
Rabbit carotid artery model
Comparison
Balloon denudation vs Control (uninjured) endothelial cells
Design
Preclinical
Follow-up
6 weeks
Authors
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May caution against assuming full functional recovery after endothelial injury in procedures; leaves open mechanistic roles of dimethylarginines in human restenosis.
p-value: p=<0.05
Accumulation of endogenous NO synthesis inhibitors (L-NMMA, ADMA) and decreased L-arginine are associated with impaired NO production and neointima formation in regenerated endothelial cells after balloon injury.
Azuma et al. (1995) studied Endothelial cell regeneration after balloon denudation. Balloon denudation of the carotid artery vs. Control endothelial cells was evaluated on L-NMMA, ADMA, and L-arginine contents in regenerated endothelial cells (p=<0.05). Regenerated endothelial cells 6 weeks after balloon denudation in rabbits showed significantly higher L-NMMA and ADMA contents and decreased L-arginine compared to control cells.
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