Key result
TIMP-4 levels were reduced in cardiomyopathic hearts, and experimental application of TIMP-4 inhibited cardiac fibroblast migration and induced apoptosis in transformed cells.
Population
Human heart end-stage explants and cultured normal and polyomavirus transformed cardiac fibroblast cells
Comparison
Tissue inhibitor of metalloproteinase-4 (TIMP-4) vs Absence of TIMP-4; normal heart tissue
Design
Preclinical
Authors
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Supports TIMP-4 investigation in cardiac fibrosis; leaves open clinical translation from cell data.
Tummalapalli et al. (2001) studied Ischemic and dilated cardiomyopathy (n=17). TIMP-4 vs. Absence of TIMP-4 / normal heart tissue was evaluated on Apoptosis, cell migration, and collagen gel invasion. TIMP-4 levels were reduced in cardiomyopathic hearts, and experimental application of TIMP-4 inhibited cardiac fibroblast migration and induced apoptosis in transformed cells.
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