July 2, 1976Science315 citations
View Full PaperIsolations of a Cartilage Factor That Inhibits Tumor Neovascularization
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Abstract
A cartilage fraction isolated by guanidine extraction and purified by affinity chromatography inhibits tumor-induced vascular proliferation and consequently restricts tumor growth. This fraction contains several different proteins; the major one has a molecular weight of about 16,000. The fraction strongly inhibits protease activity.
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Langer et al. (Fri,) studied this question.