Key result
Exogenous and SMC-derived adenosine induce nitric oxide synthesis via A2B receptors linked to a pathway not involving adenylyl cyclase/protein kinase A.
Population
Aortic smooth muscle cells (SMCs) in confluent monolayers
Design
Preclinical
Authors
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No immediate change to hypertension practice; leaves open A2B modulation as a research target.
The cyclic AMP-adenosine pathway induces nitric oxide synthesis in vascular smooth muscle cells via A2B adenosine receptors, highlighting a potential mechanism for vascular regulation.
Dubey et al. (1998) studied this question. Adenosine and cyclic AMP pathway agents was evaluated on Nitric oxide (NO) synthesis (nitrite/nitrate levels and 3H-L-citrulline formation). Exogenous and SMC-derived adenosine induce nitric oxide synthesis via A2B receptors linked to a pathway not involving adenylyl cyclase/protein kinase A.
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