Key result
Exogenous and endogenous adenosine inhibited fetal calf serum-induced rat cardiac fibroblast proliferation in a concentration-dependent manner via activation of A2B receptors.
Population
Rat cardiac fibroblasts (growth-arrested, stimulated with 2.5% fetal calf serum)
Comparison
Adenosine, 2-chloroadenosine, or modulators of… vs Absence of adenosine or its modulators
Design
Preclinical
Authors
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May limit fibroblast proliferation in remodeling; hypothesis-generating for A2B-targeted therapies but leaves open human translation.
Adenosine inhibits cardiac fibroblast proliferation via A2B receptors, highlighting a potential endogenous mechanism regulating cardiac remodeling.
Dubey et al. (1997) studied Cardiac hypertrophy/remodeling (in vitro model). Adenosine and adenosine modulators vs. Absence of adenosine/modulators was evaluated on Cardiac fibroblast proliferation (DNA synthesis and cell counting). Exogenous and endogenous adenosine inhibited fetal calf serum-induced rat cardiac fibroblast proliferation in a concentration-dependent manner via activation of A2B receptors.
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