Population
Adult rat cardiac fibroblasts (CF)
Comparison
Pharmacological treatment or genetic… vs Unmodified or untreated cardiac fibroblasts
Design
Preclinical
Authors
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A2bR modulation may curb fibroblast activity in models; leaves open translation to human antifibrotic therapies.
Adenosine A2b receptors are critically involved in the adenosine-mediated inhibition of cardiac fibroblast functions, highlighting a potential therapeutic target for cardiac fibrosis.
Chen et al. (2004) studied this question.
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