Key result
Acute increases in extracellular glucose and diabetes stimulate CaV1.2 channel activity and vasoconstriction through AKAP150-targeted PKA phosphorylation of the alpha1C subunit at Ser1928.
Why the study?
Does targeting Ser 1928 phosphorylation by PKA prevent vascular pathologies associated with diabetes?
Does targeting Ser 1928 phosphorylation by PKA prevent vascular pathologies associated with diabetes?
Targeting the protein complex that phosphorylates Ca V 1.2 may offer a therapeutic strategy to prevent vascular pathologies in diabetes.
May guide targeted therapy development for diabetic vasculopathy; leaves open whether Ser1928 modulation alters human outcomes.
Targeting a protein complex that phosphorylates the calcium channel Ca V 1.2 in arteries may prevent vascular pathologies associated with diabetes.
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Nystoriak et al. (2017) studied Hyperglycemia and diabetes. Hyperglycemia and High-Fat Diet vs. Normoglycemia and Low-Fat Diet was evaluated on CaV1.2 channel activity and Ser1928 phosphorylation. Acute increases in extracellular glucose and diabetes stimulate CaV1.2 channel activity and vasoconstriction through AKAP150-targeted PKA phosphorylation of the alpha1C subunit at Ser1928.
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