Key result
Phosphorylation by protein kinase A, stimulated by beta-adrenoceptors and adenylate cyclase, enhances delayed rectifier K+ current in rabbit vascular smooth muscle cells.
Population
Isolated rabbit portal vein smooth muscle cells
Comparison
Modulation of PKA activity vs Control conditions
Design
Preclinical
Authors
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PKA-enhanced IdK may alter vascular tone; leaves open its role in human smooth muscle disorders.
This study provides the first evidence that beta-adrenoceptor and PKA-mediated signal transduction regulates delayed rectifier K+ channels in vascular smooth muscle.
Aiello et al. (1995) studied this question. Protein kinase A (PKA) activation (via Forskolin or Isoproterenol) was evaluated on 4-aminopyridine (4-AP)-sensitive delayed rectifier current (IdK). Phosphorylation by protein kinase A, stimulated by beta-adrenoceptors and adenylate cyclase, enhances delayed rectifier K+ current in rabbit vascular smooth muscle cells.
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