August 1, 1998AJP Heart and Circulatory Physiology

β-Adrenoceptor activation and PKA regulate delayed rectifier K+channels of vascular smooth muscle cells

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Population

Rabbit portal vein myocytes

Comparison

Isoproterenol or purified catalytic subunit of PKA vs Control conditions

Design

Preclinical

Authors

EAErnesto A. AielloCentro de Investigaciones Cardiovasculares AMA. Todd MalcolmUniversity of Calgary MWMichael P. WalshUniversity College Dublin

Discussion

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Implication

Supports beta-adrenergic modulation of vascular K+ channels in animal models; leaves open clinical relevance in humans.

Structured PICO

Population

Rabbit portal vein myocytes

Intervention

Isoproterenol (1 microM) or purified catalytic subunit of PKA (50 nM)

Comparator

Control conditions

Outcome

Open probability (NPo) of delayed rectifier K+ (KDR) channelssurrogate

Beta-adrenoceptor activation and PKA phosphorylation enhance the activity of small-conductance delayed rectifier K+ channels in vascular smooth muscle cells.

Cite This Study

Aiello et al. (1998) studied this question.

synapsesocial.com/papers/6a70dcd58031ec7bb1dca262 https://doi.org/10.1152/ajpheart.1998.275.2.h448

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β-Adrenoceptor activation and PKA regulate delayed rectifier K+channels of vascular smooth muscle cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

β-Adrenoceptor activation and PKA regulate delayed rectifier K+channels of vascular smooth muscle cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider