Key result
In patients with type 1 diabetes, a treatment-induced 10% increase in time in range using sensor-augmented insulin pumps was associated with a 19% decrease in albuminuria (95% CI 10-28; P=0.04).
Why the study?
The study was conducted to investigate the association between treatment-induced changes in continuous glucose monitoring time in range and albuminuria in persons with type 1 diabetes treated with sensor-augmented insulin pumps.
Does increased time in range with sensor-augmented insulin pump therapy reduce albuminuria in patients with type 1 diabetes?
RCT (n=55)
randomized
Does increased time in range with sensor-augmented insulin pump therapy reduce albuminuria in patients with type 1 diabetes?
Effect estimate: 19% decrease per 10% increase in TIR (95% CI 10-28)
p-value: p=0.04
Improved TIR may associate with less albuminuria in T1D on SAP; leaves open whether targeting TIR alters renal outcomes.
OBJECTIVE To investigate the association between treatment-induced change in continuous glucose monitoring (CGM) time in range (TIR) and albuminuria in persons with type 1 diabetes (T1D) treated with sensor-augmented insulin pumps (SAP). RESEARCH DESIGN AND METHODS Twenty-six out of 55 participants with albuminuria and multiple daily injection therapy (25% females; median 51 [interquartile range 46–63] years of age; glycated hemoglobin A1c (HbA1c) 75 [68–88] mmol/mol [9.0% (8.4–10.4%)]; and urinary albumin-to-creatinine ratio (UACR) 89 [37–250] mg/g) were in a randomized controlled trial assigned to SAP therapy for 1 year. Anthropometrics, CGM data, and blood and urine samples were collected every 3 months. RESULTS Mean change (95% CI) in percentage of TIR (%TIR) was 13.2% (6.2; 20.2), in HbA1c was −14.4 (−17.4; −10.5) mmol/mol (−1.3% [−1.6; −1.0]), and in UACR was −15% (−38; 17) (all P < 0.05). UACR decreased by 19% (10; 28) per 10% increase in %TIR (P = 0.04), 18% (1; 30) per 10 mmol/mol decrease in HbA1c (P = 0.07), and 31% per 10-mmHg decrease in mean arterial pressure (P < 0.001). CONCLUSIONS In this longitudinal study, treatment-induced increase in %TIR was significantly associated with decrease in albuminuria in T1D.
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Ranjan et al. (2020) conducted an RCT in Type 1 diabetes with albuminuria (n=55). Sensor-augmented insulin pumps (SAP) vs. Multiple daily injection therapy was evaluated on Association between treatment-induced change in continuous glucose monitoring time in range (TIR) and albuminuria (UACR) (19% decrease per 10% increase in TIR, 95% CI 10-28, p=0.04). In patients with type 1 diabetes, a treatment-induced 10% increase in time in range using sensor-augmented insulin pumps was associated with a 19% decrease in albuminuria (95% CI 10-28; P=0.04).
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