Key result
A review of the literature highlights that the newly recognized caspase-independent apoptosis pathway may play an important but poorly understood role in cardiovascular diseases.
This review highlights the emerging role and mechanisms of caspase-independent apoptosis in cardiovascular diseases.
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Caspase-independent cardiac apoptosis remains poorly understood; leaves open its therapeutic targeting beyond caspase inhibition in cardiovascular disease.
Apoptosis plays an important role in various cardiovascular diseases, and inhibition of cardiac apoptosis shows promise as a therapeutic strategy. Caspase, a critical enzyme in the induction and execution of apoptosis, has been targeted to inhibit apoptosis. However a newly recognized caspase-independent apoptosis pathway may also play an important role in cardiac apoptosis. Yet the mechanism and the potential significance of caspase-independent apoptosis in the heart remain poorly understood. In this paper, we reviewed the literatures on the mechanism of caspase-independent apoptosis and its significance in cardiovascular diseases.
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Soochan Bae (2007) conducted a review in Cardiovascular diseases. Caspase-independent apoptosis was evaluated. A review of the literature highlights that the newly recognized caspase-independent apoptosis pathway may play an important but poorly understood role in cardiovascular diseases.
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