Key result
Administration of doxorubicin under hyperthermic conditions repeatedly produced acute synergistic cardiotoxic effects, including ventricular irritability and cardiac dysfunction, in a single patient.
Why the study?
Does whole-body hyperthermia potentiate doxorubicin-related cardiotoxic effects in a patient with metastatic cancer?
Case Report (n=1)
Does whole-body hyperthermia potentiate doxorubicin-related cardiotoxic effects in a patient with metastatic cancer?
Whole-body hyperthermia synergistically potentiates doxorubicin-induced cardiotoxicity, causing significant cardiac dysfunction and ventricular irritability at lower doses.
Answers are grounded in this paper and cite their sources.
May indicate risk with concurrent doxorubicin and hyperthermia; leaves open catecholamine role in cardiotoxicity.
The intercurrent administration of doxorubicin hydrochloride to a patient undergoing whole-body hyperthermia for the treatment of metastatic cancer repeatedly produced ventricular irritability and cardiac dysfunction. Individually, doxorubicin and hyperthermia were tolerated by the patient without incident. Catecholamine determinations showed that the administration of doxorubicin under hyperthermic conditions increased the liberation of both epinephrine and norepinephrine. The acute synergistic cardiotoxic effects occurred with doxorubicin dosages that were severalfold less than those associated with only mild and transient ECG disturbances under normothermic conditions.
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Young Duk Kim (1979) conducted a case report in Metastatic cancer (n=1). Doxorubicin hydrochloride under hyperthermic conditions vs. Doxorubicin under normothermic conditions or hyperthermia alone was evaluated on Ventricular irritability and cardiac dysfunction. Administration of doxorubicin under hyperthermic conditions repeatedly produced acute synergistic cardiotoxic effects, including ventricular irritability and cardiac dysfunction, in a single patient.
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