September 1, 1980Journal of Cardiovascular Pharmacology
Acute and Chronic Cardiovascular Effects of Doxorubicin in the Dog
Key result
Doxorubicin administration in dogs produced profound hemodynamic changes mediated by histamine and catecholamine release, which may contribute to the pathogenesis of anthracycline cardiomyopathy.
Population
open-chest dog model
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Hypothesis-generating for histamine-mediated anthracycline cardiotoxicity; leaves open translation to human prevention strategies.
Structured PICO
P
Population
Dogs evaluated for acute and chronic hemodynamic effects of doxorubicin.
I
Intervention
Doxorubicin 1-4 mg/kg administered over 2 min or as a slow continuous infusion, with or without H1- and H2-receptor blockade (diphenhydramine and cimetidine) and adrenergic blockade
O
Outcome
Acute hemodynamic effectssurrogate
Doxorubicin induces acute hemodynamic changes mediated by the release of vasoactive substances like histamine and catecholamines, which may contribute to the pathogenesis of anthracycline-induced cardiomyopathy.
Cite This Study
Bristow et al. (1980) studied Cardiovascular effects of doxorubicin. Doxorubicin was evaluated on Hemodynamic changes and release of vasoactive substances (histamine, catecholamines, prostaglandins). Doxorubicin administration in dogs produced profound hemodynamic changes mediated by histamine and catecholamine release, which may contribute to the pathogenesis of anthracycline cardiomyopathy.