August 1, 2006American Journal of Veterinary Research

Neurohormonal, hemodynamic, and electrocardiographic evaluations of healthy dogs receiving long-term administration of doxorubicin

View Full Paper

Ask AI

Bookmark

Why the study?

Does doxorubicin administration induce early detectable echocardiographic and biomarker alterations in healthy dogs?

Population

13 adult mixed-breed dogs

Comparison

Doxorubicin chloride vs Saline solution

Design

Preclinical

Follow-up

168 days

Authors

RSRute Chamié Alves de SouzaUniversidade Federal Rural de Pernambuco ACAparecido Antônio CamachoUniversidade Estadual Paulista (Unesp)

Discussion

Member takes

Implication

Supports echocardiography and PRA as early markers in canine doxorubicin models; leaves open clinical translation.

Structured PICO

Does doxorubicin administration induce early detectable echocardiographic and biomarker alterations in healthy dogs?

Population

13 adult mixed-breed dogs

Intervention

Doxorubicin chloride (30 mg/m2, IV, q 21 d for 168 days [cumulative dose, 240 mg/m2])

Comparator

Saline (0.9% NaCl) solution (5 mL, IV, q 21 d for 168 days)

Outcome

Echocardiography, ECG, arterial blood pressure, plasma renin activity (PRA), and plasma concentrations of norepinephrine and brain natriuretic peptide (BNP)surrogate

Echocardiography and plasma renin activity are able to detect early cardiac alterations in doxorubicin-induced cardiotoxicosis in a canine model.

Cite This Study

Souza et al. (2006) studied this question.

synapsesocial.com/papers/6a873693ed1c9801b3cfa680 https://doi.org/10.2460/ajvr.67.8.1319

Topics

Echocardiography

View Full Paper

Ask AI

Bookmark

August 1, 2006American Journal of Veterinary Research

Neurohormonal, hemodynamic, and electrocardiographic evaluations of healthy dogs receiving long-term administration of doxorubicin

View Full Paper

Ask AI

Bookmark

Why the study?

Does doxorubicin administration induce early detectable echocardiographic and biomarker alterations in healthy dogs?

Population

13 adult mixed-breed dogs

Comparison

Doxorubicin chloride vs Saline solution

Design

Preclinical

Follow-up

168 days

Authors

RSRute Chamié Alves de SouzaUniversidade Federal Rural de Pernambuco ACAparecido Antônio CamachoUniversidade Estadual Paulista (Unesp)

Discussion

Member takes

Implication

Supports echocardiography and PRA as early markers in canine doxorubicin models; leaves open clinical translation.

Structured PICO

Does doxorubicin administration induce early detectable echocardiographic and biomarker alterations in healthy dogs?

Population

13 adult mixed-breed dogs

Intervention

Doxorubicin chloride (30 mg/m2, IV, q 21 d for 168 days [cumulative dose, 240 mg/m2])

Comparator

Saline (0.9% NaCl) solution (5 mL, IV, q 21 d for 168 days)

Outcome

Echocardiography, ECG, arterial blood pressure, plasma renin activity (PRA), and plasma concentrations of norepinephrine and brain natriuretic peptide (BNP)surrogate

Echocardiography and plasma renin activity are able to detect early cardiac alterations in doxorubicin-induced cardiotoxicosis in a canine model.

Cite This Study

Souza et al. (2006) studied this question.

synapsesocial.com/papers/6a873693ed1c9801b3cfa680 https://doi.org/10.2460/ajvr.67.8.1319

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Topics

Echocardiography

View Full Paper

Ask AI

Bookmark