What question did this study set out to answer?

To evaluate the efficacy of 24-hour Holter electrocardiography in detecting early heart rate alterations and arrhythmias in dogs with doxorubicin-induced dilated cardiomyopathy.

December 1, 2006Arquivo Brasileiro de Medicina Veterinária e ZootecniaOpen Access

Holter electrocardiography in dogs showing doxorubicin-induced dilated cardiomyopathy

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Why the study?

Does 24-hour Holter monitoring detect early heart rate and cardiac rhythm alterations in dogs with doxorubicin-induced myocardial dysfunction compared to controls?

Population

10 healthy dogs assigned to a doxorubicin-induced cardiomyopathy model (n=5) or control group (n=5).

Comparison

Doxorubicin 30 mg/m² intravenously every 21 days… vs Saline administered intravenously at the same…

Design

Preclinical

Authors

GNGláucia Bueno Pereira NetoUniversidade de Brasília JAJames Newton Bizetto Meira de AndradeUniversidade Federal dos Vales do Jequitinhonha e Mucuri MSMarlos Gonçalves SousaUniversidade Federal do Paraná

Discussion

Member takes

Implication

Supports Holter detection of early HR and rhythm changes in doxorubicin-treated dogs; leaves open translation to clinical veterinary practice.

Key Points

To evaluate the efficacy of 24-hour Holter electrocardiography in detecting early heart rate alterations and arrhythmias in dogs with doxorubicin-induced dilated cardiomyopathy.
Assigned 10 healthy dogs to receive either intravenous doxorubicin (30 mg/m² every 21 days up to a cumulative dose of 180–240 mg/m²; Group B, n=5) or saline control at identical intervals (Group A, n=5).
Recorded 24-hour Holter electrocardiography in both groups following the confirmation of myocardial dysfunction in Group B (defined as shortening fraction <20%, E-point to septal separation >0.7 cm, and end-systolic left ventricular volume index of 61.4 ml/m²).
Group B dogs demonstrated a 44.6% increase in minimum heart rate and a 41.7% increase in mean heart rate compared to control animals.
Both supraventricular and ventricular arrhythmias developed following doxorubicin administration, with treated dogs displaying a higher occurrence of supraventricular arrhythmias.

Structured PICO

Does 24-hour Holter monitoring detect early heart rate and cardiac rhythm alterations in dogs with doxorubicin-induced myocardial dysfunction compared to controls?

Population

10 healthy dogs assigned to a doxorubicin-induced cardiomyopathy model (n=5) or control group (n=5).

Intervention

Doxorubicin 30 mg/m² intravenously every 21 days until a cumulative dose of 180 mg/m² or 240 mg/m² was reached, followed by 24-hour Holter monitoring upon observation of myocardial dysfunction.

Comparator

Saline administered intravenously at the same intervals, followed by 24-hour Holter monitoring.

Outcome

Heart rate and cardiac rhythm alterations (arrhythmias) detected by 24-hour Holter monitoring.surrogate

Holter monitoring effectively detects early heart rate increases and supraventricular arrhythmias in a canine model of doxorubicin-induced cardiomyopathy.

Cite This Study

Neto et al. (2006) studied this question.

synapsesocial.com/papers/6a8bd6fd039371f2a3896cd3 https://doi.org/10.1590/s0102-09352006000600010

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Implication

Supports Holter detection of early HR and rhythm changes in doxorubicin-treated dogs; leaves open translation to clinical veterinary practice.

Holter electrocardiography in dogs showing doxorubicin-induced dilated cardiomyopathy

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Holter electrocardiography in dogs showing doxorubicin-induced dilated cardiomyopathy

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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