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In 3 mongoloid patients aged respectively 47, 42, and 37 years, personality changes and mental deterioration were observed. Pathologically, evidence of senile changes was obtained consisting of degeneration of neurons, numerous senile plaques, and Alzheimer's neurofibrillary changes. With the exception of the age of onset, the clinical and pathological manifestations are those of senile dementia. Since mongoloid patients show a marked tendency to develop this type of reaction, it is suggested that the study of it offers some information which may contribute to a better understanding of the causes of senile dementia.
George A. Jervis (Sun,) studied this question.