Key result
Personalized perioperative vasopressor selection favors patient-specific hemodynamic profiles over a rigid hierarchy.
Why the study?
Despite vasopressors being central to intraoperative hypotension management, optimal agent selection, timing, and titration remain unclear and variable.
Optimal choice and titration of intraoperative vasopressors in noncardiac surgery lack robust comparative evidence, requiring an individualized approach based on patient hemodynamic profiles rather than a prescriptive hierarchy.
Should not yet change vasopressor practice; leaves open need for RCTs validating hemodynamic-guided personalization.
In Brief Despite vasopressors being central to intraoperative hypotension management, optimal agent selection, timing, and titration remain unclear and variable. This article integrates evidence, physiology, and technology to propose a personalized vasopressor therapy framework.
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Nguyen et al. (2025) conducted a review in Perioperative hypotension in noncardiac surgical patients. Perioperative vasopressor management was evaluated. Personalized perioperative vasopressor management in noncardiac surgical patients should be guided by the patient's hemodynamic profile, surgical context, and emerging technologies rather than a prescriptive hierarchy.
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