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Time of day mitigates the therapeutic impact of neuroprotective paradigms in stroke, suggesting chronotype should be considered in experimental therapies.
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The occurrence of stroke in humans peaks in the morning. A recent study revealed that time of day mitigates the therapeutic impact of neuroprotective paradigms. These findings might not only explain the previous failure of translation of neuroprotective therapies but inspire new paradigms in stroke chronopathophysiology research. Taking chronotype into account may complement the many factors that influence efficacy of experimental therapies in stroke.
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Boltze et al. (2020) conducted an editorial in Stroke. Neuroprotective therapies and time of day was evaluated. Time of day mitigates the therapeutic impact of neuroprotective paradigms in stroke, suggesting chronotype should be considered in experimental therapies.
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