424 LABMEDICINE Volume 36 Number 7 July 2005 labmedicine.com Measurement of biochemical bone markers is a tool commonly used in clinical research on metabolic bone diseases. Because research findings in this area are applied increasingly in clinical practices, bone markers are used more and more in routine clinical testing.1-7 Although clinical research is performed in highly controlled and standardized settings with well-defined patients, routine clinical testing deals with less controlled and defined circumstances (Table 1). Therefore, knowledge of these factors affecting results of bone marker measurements is important so that this tool is applied appropriately and interpretation of results in routine clinical testing is facilitated. This review summarizes biochemical bone markers and provides an overview of analytical and preanalytical factors that affect bone marker measurements.
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Hubert W. Vesper (2005) studied this question.