Key result
A higher triglyceride-glucose index was independently associated with an increased risk of all-cause mortality or heart failure hospitalization (HR 2.01) in patients with heart failure.
Why the study?
The triglyceride–glucose (TyG) index is a surrogate marker of insulin resistance, but its association with myocardial fibrosis quantified by extracellular volume fraction and their prognostic value in heart failure remained to be evaluated.
Does the TyG index correlate with myocardial fibrosis and predict adverse outcomes in hospitalized heart failure patients?
Population
103 hospitalized HF patients
Comparison
TyG index levels and ECV fraction
Design
Retrospective cohort study
Follow-up
Median of 12.3 months
Authors
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TyG index may aid HF risk stratification; extends observational links but leaves open causal role or therapeutic targeting.
Cohort (n=103)
No
Does the TyG index correlate with myocardial fibrosis and predict adverse outcomes in hospitalized heart failure patients?
Hazard Ratio: 2.01 (95% CI 1.03–4.01)
p-value: p=0.047
The TyG index is associated with myocardial fibrosis and serves as an independent predictor of all-cause mortality and HF hospitalization in patients with heart failure.
Yang et al. (2021) conducted a cohort in Heart Failure (n=103). Higher Triglyceride-glucose (TyG) index vs. Lower TyG index was evaluated on Composite of all-cause mortality and heart failure hospitalization (HR 2.01, 95% CI 1.03-4.01, p=0.047). A higher triglyceride-glucose index was independently associated with an increased risk of all-cause mortality or heart failure hospitalization (HR 2.01) in patients with heart failure.
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