Key result
Higher extracellular volume fraction was an independent risk factor for all-cause mortality and heart failure hospitalization (HR per doubling 1.68; 95% CI 1.03-2.74).
Why the study?
Secreted frizzled-related protein 2 (SFRP2) appears to play an important role in cardiac fibrosis, but its association with myocardial fibrosis and the prognostic value of extracellular volume (ECV) fraction in heart failure needed evaluation.
Population
72 hospitalized adult patients (age >=18 years) with severe decompensated HF
Comparison
Levels of SFRP2 and ECV fraction evaluated for association and outcomes
Design
Prospective cohort study
Follow-up
Median 12 months
Authors
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ECV may enhance risk stratification in decompensated HF; leaves open whether it guides therapy or improves outcomes.
Cohort (n=72)
Hazard Ratio: 1.68 (95% CI 1.03–2.74)
Higher extracellular volume fraction and NT-proBNP independently predict adverse outcomes in severe decompensated heart failure, while SFRP2 serves as a biomarker for myocardial fibrosis.
Yang et al. (2020) conducted a cohort in severe decompensated heart failure (n=72). Extracellular volume (ECV) fraction was evaluated on Composite of all-cause mortality and heart failure hospitalization (HR 1.68, 95% CI 1.03-2.74). Higher extracellular volume fraction was an independent risk factor for all-cause mortality and heart failure hospitalization (HR per doubling 1.68; 95% CI 1.03-2.74).
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