Key result
Optogenetic stimulation of vagal pre-ganglionic neurons preserved left ventricular function and exercise capacity in a rat model of myocardial infarction-induced heart failure.
Why the study?
Clinical trials of vagus nerve stimulation in heart failure failed to show primary benefits, possibly due to nonselective stimulation.
Does optogenetic stimulation of vagal pre-ganglionic neurons preserve left ventricular function and exercise capacity in a rat model of myocardial infarction-induced heart failure?
Population
Rat model of myocardial infarction-induced heart failure
Comparison
Optogenetic stimulation of vagal pre-ganglionic neurons transduced to express light-sensitive channels
Design
Preclinical animal study
Authors
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Preserves LV function in rat HF model; leaves open translation to human vagal neuromodulation therapies.
Does optogenetic stimulation of vagal pre-ganglionic neurons preserve left ventricular function and exercise capacity in a rat model of myocardial infarction-induced heart failure?
Selective stimulation of vagal efferent activity preserves left ventricular function in experimental heart failure, suggesting that the nonselective nature of traditional vagus nerve stimulation may explain the failure of previous clinical trials.
Machhada et al. (2020) studied Myocardial infarction-induced heart failure. Optogenetic stimulation of vagal pre-ganglionic neurons was evaluated on Left ventricular function and exercise capacity. Optogenetic stimulation of vagal pre-ganglionic neurons preserved left ventricular function and exercise capacity in a rat model of myocardial infarction-induced heart failure.
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