Key result
Job strain was associated with a reduction in cardiac vagal control (P=0.02) and elevations in sympathetic control during working hours (P=0.003).
Why the study?
Does job strain alter autonomic indices of cardiovascular disease risk in healthy mid-aged males?
Observational (n=36)
Does job strain alter autonomic indices of cardiovascular disease risk in healthy mid-aged males?
Job strain is associated with disturbed autonomic cardiovascular regulation, including reduced vagal control and elevated sympathetic tone, which may explain the increased cardiovascular risk linked to occupational exposure.
Job strain links to autonomic imbalance in healthy men; leaves open mediation of occupational CVD risk in larger studies.
BACKGROUND: Despite the epidemiological evidence linking job strain to cardiovascular disease, more insight is needed into the etiologic mechanisms. This, in turn, would help to more precisely identify risk. METHODS: We measured Job Strain using the Job Content Questionnaire, 8/day diary reports, and nationally standardized occupational code linkage, as well as autonomic regulation utilizing heart rate variability including spectral-derived components and QT interval variability in 36 healthy mid-aged males with varying strain jobs. The subjects wore Holter-monitors for 48 hr; this included a work and rest day. RESULTS: Job strain (P = 0.02) and low decision latitude (P = 0.004) were associated with a reduction in cardiac vagal control (HFP) persisting throughout the 48 hr. Job strain was also associated with elevations in sympathetic control during working hours (P = 0.003). CONCLUSIONS: The disturbed cardiovascular regulatory pattern associated with job strain may help explain the increased risk of cardiovascular diseases linked with occupational exposure.
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Collins et al. (2005) conducted an observational in Healthy (n=36). Job strain was evaluated on Cardiac vagal control (HFP) and sympathetic control (p=0.02). Job strain was associated with a reduction in cardiac vagal control (P=0.02) and elevations in sympathetic control during working hours (P=0.003).
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