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Reveals efficient synthesis of 3-hydroxyazetidines, indicating scalable chemical production.
A photo‐flow Norrish–Yang cyclisation has been devised that delivers 3‐hydroxyazetidines in good yields. The high reproducibility and short residence times of the flow process enables easy scaling of the transformation allowing access to these valuable chemical entities at synthetically useful multi‐gram scales. A systematic exploration of the constituent structural components was undertaken allowing an understanding of the reactivity and functional group tolerance of the transformation.
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Ruggeri et al. (2019) studied this question.
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