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Abstract Styrenes represent a challenging class of substrates for current radical trifluoromethylation and hydrotrifluoromethylation methods due to a myriad of potential side reactions. Herein, we describe the development of mild, selective and broadly applicable photocatalytic trifluoromethylation and hydrotrifluoromethylation protocols for these challenging substrates. The methods use fac‐Ir(ppy) 3 , visible light and inexpensive CF 3 I and can be applied to a diverse set of vinylarene substrates. The use of continuous‐flow photochemical reaction conditions allowed to reduce the reaction time and increase the reaction selectivity.
Straathof et al. (Tue,) studied this question.