Key result
Cardiovascular risk factors were strongly associated with CAC progression over 10 years, including diabetes (31.3 Agatston units/year; 95% CI 27.4-35.3), male sex, and hypertension.
Why the study?
What are the cardiovascular disease risk factors associated with long-term coronary artery calcium progression in adults without preexisting cardiovascular disease?
Population
6,810 adults without preexisting cardiovascular disease from a multiethnic cohort
Design
Cohort
Follow-up
10 years
Authors
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May inform risk factor control to limit CAC progression; extends prior short-term data in multiethnic adults.
Cohort (n=6,810)
Yes
What are the cardiovascular disease risk factors associated with long-term coronary artery calcium progression in adults without preexisting cardiovascular disease?
Mean Difference: 31.3 (95% CI 27.4–35.3)
Long-term coronary artery calcium progression is strongly driven by traditional cardiovascular risk factors, particularly diabetes, male sex, age, and hypertension.
Gassett et al. (2015) conducted a cohort in Coronary atherosclerosis (n=6,810). Cardiovascular disease risk factors (e.g., diabetes, hypertension, male sex, age) vs. Absence of respective risk factors was evaluated on Coronary artery calcium (CAC) progression (MD 31.3 Agatston units/year (for diabetes), 95% CI 27.4 to 35.3). Cardiovascular risk factors were strongly associated with CAC progression over 10 years, including diabetes (31.3 Agatston units/year; 95% CI 27.4-35.3), male sex, and hypertension.
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