April 15, 2008Radiology
Coronary Calcium Coverage Score: Determination, Correlates, and Predictive Accuracy in the Multi-Ethnic Study of Atherosclerosis
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Implication
Randomized trial demonstrates the predictive value of coronary calcium score in cardiovascular events, highlighting important risk factors.
Key Points
- This research aimed to develop a new coronary calcium score to evaluate calcified plaque in arteries and its relationship to cardiovascular risk factors and events.
- Calculated coronary calcium coverage score (CCS) in 3252 participants using unenhanced cardiac CT.
- Utilized quasi-Poisson models and Cox proportional hazards models to analyze associations and predict cardiovascular events.
- Assessed predictive ability using area under the receiver operating characteristic curves and bootstrap t tests.
- CCS was significantly associated with hypertension, dyslipidemia, and diabetes (P < .001).
- A twofold increase in CCS corresponded to a 52% increase in risk for coronary heart disease (CHD) events (95% CI: 34%, 72%).
- CCS outperformed Agatston and mass scores in predicting CHD events, despite no differences found in predicting hard cardiac events.
Cite This Study
Brown et al. (2008) studied this question.