Key result
Acute myocardial infarction patients treated with PCI had significantly higher levels of IL-6, CRP, and IL-10 up to 14 days post-procedure compared to patients with stable angina pectoris.
Why the study?
Does the inflammatory response after percutaneous coronary intervention differ between patients with acute myocardial infarction and those with stable angina pectoris?
Observational (n=30)
Does the inflammatory response after percutaneous coronary intervention differ between patients with acute myocardial infarction and those with stable angina pectoris?
Patients with acute myocardial infarction exhibit a more pronounced short-term increase in both pro- and anti-inflammatory mediators following PCI compared to those with stable angina.
Answers are grounded in this paper and cite their sources.
Similar post-PCI IL-6 rise in AMI and stable AP; extends inflammatory profiling without practice change.
OBJECTIVE: To investigate the profile of circulating inflammatory markers after percutaneous coronary intervention (PCI) in patients with AMI or stable angina pectoris (AP). MATERIAL AND METHODS: Twenty patients with AMI and 10 with stable AP were treated with PCI of a central coronary artery. Blood samples were drawn immediately before PCI, in the AP group and after 3 and 12 h, days 1, 3, 5, 7 and 14 in both groups. RESULTS: Interleukin 6 increased in both groups to time-point 12 h and day 1 (peak), being significantly higher in the AMI group compared to the AP group at 3 and 12 h, and also at days 1 and 3. A similar profile was demonstrated for CRP with significantly higher levels in the AMI group at days 1, 3 and 5 compared to the AP group. A slightly different pattern was shown for Interleukin 10 (IL-10) with significantly higher levels in the AMI group at 3 and 12 h, days 1 and 14 compared to the AP group. CONCLUSION: AMI patients treated with PCI experienced a marked short-term increase in pro-inflammatory mediators as well as IL-10 compared to patients with stable angina pectoris treated with PCI.
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Solheim et al. (2008) conducted an observational in Acute myocardial infarction or stable angina pectoris (n=30). Acute myocardial infarction vs. Stable angina pectoris was evaluated on Circulating inflammatory markers (IL-6, CRP, IL-10). Acute myocardial infarction patients treated with PCI had significantly higher levels of IL-6, CRP, and IL-10 up to 14 days post-procedure compared to patients with stable angina pectoris.
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