Key result
Coronary angioplasty and angiography significantly increased inflammatory markers in unstable angina patients with raised baseline levels (P<0.001), but not in stable angina patients.
Why the study?
Does the inflammatory response to PTCA or diagnostic angiography differ between patients with stable versus unstable angina?
Population
113 patients total: 30 with stable angina and 56 with unstable angina undergoing single-vessel PTCA; 12 with…
Comparison
Single-vessel PTCA or diagnostic coronary… vs Stable angina patients
Design
Cohort
Follow-up
72 hours
Authors
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May reflect disease-specific hyperreactivity in unstable angina; hypothesis-generating, should not yet change practice.
Observational (n=113)
Does the inflammatory response to PTCA or diagnostic angiography differ between patients with stable versus unstable angina?
p-value: p=<0.001
Patients with unstable angina and elevated baseline inflammatory markers exhibit a hyperresponsive inflammatory reaction to both PTCA and diagnostic angiography, suggesting systemic inflammation plays a role in the pathogenesis of unstable angina.
Liuzzo et al. (1998) conducted an observational in Stable and unstable angina (n=113). Single-vessel PTCA or diagnostic coronary angiography vs. Stable angina was evaluated on Time course of CRP, SAA, and IL-6 after procedure (p=<0.001). Coronary angioplasty and angiography significantly increased inflammatory markers in unstable angina patients with raised baseline levels (P<0.001), but not in stable angina patients.