What is the clinical evidence from this study?

Study design: Review. Intervention: Acetylcholine and Adrenaline.

What question did this study set out to answer?

The aim is to summarize the activation and deactivation mechanisms of pacemaker currents in cardiac tissue.

August 1, 1979Journal of Experimental BiologyOpen Access

Cardiac Pacemaker Oscillation and Its Modulation by Autonomic Transmitters

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Key result

Acetylcholine inhibits pacemaker cells by increasing outward potassium current, whereas adrenaline accelerates pacemaking by increasing slow inward current.

Population

Pacemaking tissue of the frog and rabbit (amphibian and mammalian sino-atrial node)

Design

Review

Authors

HBHilary F. BrownUniversity of Oxford DDDario DiFrancescoElectrophysiology SNSusan NobleGoogle (United States)

Discussion

Member takes

Implication

Early animal voltage-clamp data map pacemaker currents; leaves open human sinoatrial node translation.

Key Points

The aim is to summarize the activation and deactivation mechanisms of pacemaker currents in cardiac tissue.
Utilized the voltage-clamp technique for experimental analysis in frog and rabbit pacemaker cells.
Investigated the effects of acetylcholine and adrenaline on membrane currents in pacemaker cells.
Acetylcholine inhibits slow inward current and increases outward potassium current in amphibians and mammals.
Adrenaline increases slow inward current, leading to accelerated pacemaking rates despite increased outward current.

Structured PICO

Population

Pacemaking tissue of the frog and rabbit (amphibian and mammalian sino-atrial node)

Exposure

Acetylcholine and adrenaline

Outcome

Modulation of membrane currents underlying pacemakingsurrogate

This review summarizes the ionic mechanisms by which autonomic transmitters modulate cardiac pacemaker activity.

Cite This Study

Brown et al. (1979) reported a review. Acetylcholine and Adrenaline was evaluated. Acetylcholine inhibits pacemaker cells by increasing outward potassium current, whereas adrenaline accelerates pacemaking by increasing slow inward current.

synapsesocial.com/papers/6a63fb208f9af43445385f9f https://doi.org/10.1242/jeb.81.1.175

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Cardiac Pacemaker Oscillation and Its Modulation by Autonomic Transmitters

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Cardiac Pacemaker Oscillation and Its Modulation by Autonomic Transmitters

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider