Key result
Concomitant central ECMO and IABP therapy led to a significant reduction of left ventricular pressure compared to retrograde flow in peripheral ECMO in a porcine model.
Why the study?
Simultaneous ECMO and IABP therapy is frequently used, but the haemodynamic changes responsible for the success of this combined mechanical circulatory support approach are rarely investigated.
Does concomitant IABP reduce left ventricular pressure during central VA-ECMO in a porcine model?
Population
Thirty-three female pigs
Comparison
SHAM vs (p)ECMO(-)IABP vs (p)ECMO(+)IABP vs (c)ECMO(-)IABP vs (c)ECMO(+)IABP
Design
Large-animal experimental study
Follow-up
10 h
Authors
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Supports LV unloading rationale with central ECMO+IABP; hypothesis-generating, requires human trials before practice change.
Does concomitant IABP reduce left ventricular pressure during central VA-ECMO in a porcine model?
In a porcine model, adding IABP to central VA-ECMO significantly reduces left ventricular pressure and cardiac work, providing a physiological rationale for this concomitant mechanical support strategy.
Djordjevic et al. (2022) studied Extracorporeal Membrane Oxygenation (ECMO) support (n=33). Concomitant central ECMO and IABP therapy vs. Peripheral ECMO with or without IABP, central ECMO without IABP, and SHAM was evaluated on Left ventricular pressure and systemic haemodynamics. Concomitant central ECMO and IABP therapy led to a significant reduction of left ventricular pressure compared to retrograde flow in peripheral ECMO in a porcine model.
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