Fluorophore plus a macrocyclic polyamine blend into a probe for zinc that is active under physiological conditions. Compound 1 (X=Cl) increased fluorescence intensity 26-fold upon addition of ZnII, yet is insensitive to other common metals. The probes are active at a range of pH values, most importantly at pH 7. These probes do not need biologically harmful UV irradiation for fluoroescent activity.
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Hirano et al. (2000) studied this question.