Key result
The MTHFR 677TT genotype was associated with increased susceptibility to type 2 diabetes mellitus (OR 2.2, p=0.01) and complications including diabetic retinopathy, polyneuropathy, and ischemic heart disease.
Why the study?
Are ACE and MTHFR genetic polymorphisms associated with susceptibility to and complications of type 2 diabetes mellitus?
Population
514 Egyptian subjects, comprising 203 patients with type 2 diabetes mellitus (T2DM) and 311 healthy controls.
Comparison
Presence of ACE I>D and MTHFR genetic… vs Absence of these polymorphisms / healthy controls
Design
Case-control
Authors
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MTHFR 677TT may flag higher T2DM complication risk in Egyptians; leaves open validation before any genotyping role in prevention.
Case-Control (n=514)
Are ACE and MTHFR genetic polymorphisms associated with susceptibility to and complications of type 2 diabetes mellitus?
Odds Ratio: 2.2
p-value: p=0.01
MTHFR and ACE genetic polymorphisms are associated with increased susceptibility to type 2 diabetes and its microvascular and macrovascular complications in an Egyptian population.
Settin et al. (2014) conducted a case-control in Type 2 diabetes mellitus (n=514). ACE and MTHFR genetic polymorphisms vs. Healthy controls / absence of specific genotypes was evaluated on Susceptibility to type 2 diabetes mellitus (OR 2.2, p=0.01). The MTHFR 677TT genotype was associated with increased susceptibility to type 2 diabetes mellitus (OR 2.2, p=0.01) and complications including diabetic retinopathy, polyneuropathy, and ischemic heart disease.