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Assesses ligand display control on gold nanoparticles for cell targeting, suggesting polymer use may enhance specificity.
The function of cell-specific ligands on gold nanoparticles can be selectively gated by the action of co-grafted thermosensitive polymers. Below the LCST the responsive chain-extended polymers prevent cell-surface receptors from accessing the affinity ligands while above the LCST, the polymers collapse exposing the ligands and allowing binding to receptors, which in turn promotes cell internalisation.
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Mastrotto et al. (2011) studied this question.
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