Mast cell modulation: A novel therapeutic strategy for abdominal pain in irritable bowel syndrome

Irritable bowel syndrome (IBS) is one of the most prevalent gastrointestinal disorders characterized by recurrent abdominal pain and an altered defecation pattern. Chronic abdominal pain represents the hallmark IBS symptom and is reported to have the most bothersome impact on the patient’s quality of life. Unfortunately, effective therapeutic strategies reducing abdominal pain are lacking, mainly attributed to a limited understanding of the contributing mechanisms. In the past few years, exciting new insights have pointed out that altered communication between gut immune cells and pain-sensing nerves acts as a hallmark driver of IBS-related abdominal pain. In this review, we aim to summarize our current knowledge on altered neuro-immune crosstalk as the main driver of altered pain signaling, with a specific focus on altered mast cell functioning herein, and highlight the relevance of targeting mast cell-mediated mechanisms as a novel therapeutic strategy for chronic abdominal pain in IBS patients. New insights in the pathophysiology of irritable bowel syndrome (IBS) offer the promise toward more effective therapeutic strategies for abdominal pain in patients with IBS. Van Remoortel et al. highlight exciting new mechanistic information on the role of altered neuro-immune crosstalk and its potential for treating chronic abdominal pain in IBS.