What question did this study set out to answer?

The research aims to identify potential mechanisms of developmental toxicity caused by HDAC inhibitors in human embryonic stem cells.

May 7, 2015Cell Death and DiseaseOpen Access

Neuronal developmental gene and miRNA signatures induced by histone deacetylase inhibitors in human embryonic stem cells

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Authors

KMKesavan MeganathanWashington University in St. Louis SJSmita JagtapMassachusetts General Hospital SSSureshkumar Perumal SrinivasanUniversity Hospital Cologne

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Implication

Randomized trial identifies gene and microRNA changes in human embryonic stem cells exposed to HDAC inhibitors, suggesting implications for neuronal development.

Key Points

The research aims to identify potential mechanisms of developmental toxicity caused by HDAC inhibitors in human embryonic stem cells.
Used human embryonic stem cells and specific differentiation protocols
Conducted genome-wide gene expression and microRNA profiling
Evaluated the effects of VPA, SAHA, and TSA on gene expression related to neuronal development.
VPA repressed transcripts related to neural tube and dorsal forebrain, including OTX2 and SOX10.
VPA upregulated genes associated with axonogenesis and ventral forebrain, such as SLIT1, SEMA3A, and DLX2/4.
miR-378 expression was induced by HDAC inhibitors, and its knockdown increased OTX2 and EMX2 expression.

Cite This Study

Meganathan et al. (2015) studied this question.

synapsesocial.com/papers/6a6405447ff024ad28385b05 https://doi.org/10.1038/cddis.2015.121

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Implication

Randomized trial identifies gene and microRNA changes in human embryonic stem cells exposed to HDAC inhibitors, suggesting implications for neuronal development.

Neuronal developmental gene and miRNA signatures induced by histone deacetylase inhibitors in human embryonic stem cells

Discussion

Member takes

Implication

Key Points

Cite This Study

Neuronal developmental gene and miRNA signatures induced by histone deacetylase inhibitors in human embryonic stem cells

Discussion

Member takes

Implication

Key Points

Cite This Study

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