Answers are grounded in this paper and cite their sources.
Meta-analysis demonstrates better adherence to once-daily antiretroviral regimens in diverse trials, suggesting improved outcomes.
Once-daily regimens of antiretroviral therapy are simpler than other regimens, but whether such regimens are associated with better adherence to treatment is controversial. We performed a meta-analysis of 11 randomized, controlled trials (total number of subjects, 3029), which revealed that the adherence rate was better with once-daily regimens (+2.9%; 95% confidence interval, 1.0%-4.8%; P < .003) than with twice-daily regimens. This modest effect was more pronounced at the time of treatment initiation and for regimens for which all medications were taken once per day.
No takes yet. Share an insight, caveat, or question.
Parienti et al. (2009) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: