Key result
Older age was associated with attenuated regional sweating thresholds and rates during whole body heating compared to young subjects (P<0.0001), while cholinergic sensitivity remained similar.
Why the study?
Does aging attenuate regional sweating and skin blood flow responses to thermal and pharmacological stimuli?
Population
17 healthy subjects, comprising 8 aged (64 ± 7 yr) and 9 young (23 ± 3 yr) individuals
Comparison
ACh dose response (1 × 10 to 0.1 M) and passive… vs Young subjects (23 ± 3 yr)
Design
Cross-sectional
Authors
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Regional decrements in heat-activated sweating may heighten heat strain in older adults; leaves open cholinergic pathways for targeted interventions.
Cross-Sectional (n=17)
Does aging attenuate regional sweating and skin blood flow responses to thermal and pharmacological stimuli?
p-value: p=<0.0001
Aging is associated with regional decrements in heat-activated sweat gland function but not cholinergic sensitivity, potentially compromising thermoregulation during heat exposure.
Smith et al. (2013) conducted a cross-sectional in Healthy (n=17). Older age vs. Young age was evaluated on Regional sweating thresholds and regional sweating (RSR) during whole body heating (p=<0.0001). Older age was associated with attenuated regional sweating thresholds and rates during whole body heating compared to young subjects (P<0.0001), while cholinergic sensitivity remained similar.
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