Key result
Children with urolithiasis exhibited higher carotid intima-media thickness and biventricular myocardial performance indexes compared to healthy controls, indicating early subclinical atherosclerosis and cardiac dysfunction.
Why the study?
Does urolithiasis increase subclinical cardiovascular risk and alter ventricular functions in children?
Case-Control (n=34)
No
Does urolithiasis increase subclinical cardiovascular risk and alter ventricular functions in children?
Children with urolithiasis exhibit early signs of biventricular systolic and diastolic dysfunction as well as subclinical atherosclerosis compared to healthy controls.
Answers are grounded in this paper and cite their sources.
May link pediatric urolithiasis to inflammation-driven cardiovascular risk; hypothesis-generating, needs prospective confirmation.
cytokines play a role in the progression of atherosclerosis (3).Studies in the adult population indicated that urolithiasis is related to chronic systemic inflammation such as hypertension, diabetes and metabolic syndrome.Also, it has been demonstrated
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Elmacı et al. (2023) conducted a case-control in Urolithiasis (n=34). Urolithiasis vs. Healthy children without urinary stone disease was evaluated on Carotid intima-media thickness (cIMT) (p=<0.001). Children with urolithiasis exhibited higher carotid intima-media thickness and biventricular myocardial performance indexes compared to healthy controls, indicating early subclinical atherosclerosis and cardiac dysfunction.
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