Key result
Pediatric chronic kidney disease was associated with left ventricular hypertrophy and diastolic dysfunction, with low hemoglobin levels independently predicting higher E/E' ratio (β -0.470; P=0.001).
Why the study?
Are left ventricular hypertrophy and diastolic dysfunction present in early stages of pediatric chronic kidney disease as assessed by tissue Doppler echocardiography?
Cross-Sectional (n=59)
Are left ventricular hypertrophy and diastolic dysfunction present in early stages of pediatric chronic kidney disease as assessed by tissue Doppler echocardiography?
Effect estimate: β -0.470 (95% CI -0.764 to -0.196)
p-value: p=0.001
Tissue Doppler imaging reveals that left ventricular hypertrophy and diastolic dysfunction are present in early stages of pediatric CKD, with anemia being a significant independent predictor.
LVH and diastolic dysfunction may emerge early in pediatric CKD; leaves open anemia's causal role and need for prospective trials.
BACKGROUND: Cardiovascular (CV) disease remains the most common cause of mortality in chronic kidney disease (CKD). METHODS: In this cross-sectional study, 43 pediatric patients with CKD were divided into two groups according to their estimated glomerular filtration rate (eGFR): groups 1 and 2 (eGR; 29-75 and 15-29 mL/min/1.73 m(2), respectively). M - mode, conventional pulsed wave Doppler (cPWD) echocardiography and tissue Doppler imaging (TDI) were performed in all patients and 16 healthy controls. Maximal early (E wave) and late (A wave) diastolic flow velocities were assessed by cPWD. Using TDI, the early (E') and late (A') diastolic filling velocities were recorded. Early and late diastoles were evaluated using E' values and E/E' ratios, respectively. RESULTS: Left ventricular hypertrophy (LVH) was determined in 19/43 (44.2%) patients. The E/E' ratio was significantly higher in group 2 than in group 1 and controls. E/E' was found to be positively correlated with left ventricular mass (LVM) index, and negatively with hemoglobin (Hb) levels. Low Hb levels were only independent predictor of E/E' (p = 0.001, β: -0.470, 95% CI: -0.764; -0.196). E' ratio was significantly lower in both patient groups compared to the controls. CONCLUSIONS: LVH and diastolic dysfunction are already present in early stages of CKD. Treatment of risk factors, such as anemia, is important to improve the clinical outcome.
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Doğan et al. (2015) conducted a cross-sectional in Pediatric chronic kidney disease (n=59). Chronic kidney disease vs. Healthy controls was evaluated on E/E' ratio (β -0.470, 95% CI -0.764 to -0.196, p=0.001). Pediatric chronic kidney disease was associated with left ventricular hypertrophy and diastolic dysfunction, with low hemoglobin levels independently predicting higher E/E' ratio (β -0.470; P=0.001).
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